Drug interactions
Avatrombopag + Mifepristone
Severity: Moderate
Avatrombopag and Mifepristone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone inhibits CYP3A4 and may increase avatrombopag exposure. This can enhance platelet count elevation and raise the risk of thromboembolic events.
What this interaction means in plain words
Avatrombopag and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Avatrombopag belongs to Miscellaneous; Mifepristone belongs to Endocrine.
Why it happens
Inhibition of CYP3A4 (with CYP2C9 contribution) metabolism of avatrombopag by mifepristone.
What to do
Use a reduced avatrombopag starting dose when treating ITP, as per labeling. Monitor platelet counts and adjust the dose when mifepristone is started or stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Other interactions of Avatrombopag
- Amiodarone + Avatrombopag Moderate
- Amobarbital + Avatrombopag Moderate
- Avatrombopag + Bosentan Moderate
- Avatrombopag + Carbamazepine Moderate
- Avatrombopag + Enzalutamide Moderate
- Avatrombopag + Fluconazole Moderate
Frequently asked questions
Can I take Avatrombopag with Mifepristone?
MediHelp rates the interaction as moderate. Avatrombopag and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mifepristone inhibits CYP3A4 and may increase avatrombopag exposure. This can enhance platelet count elevation and raise the risk of thromboembolic events.
How serious is the interaction between Avatrombopag and Mifepristone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a reduced avatrombopag starting dose when treating ITP, as per labeling. Monitor platelet counts and adjust the dose when mifepristone is started or stopped.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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