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Interactions médicamenteuses

Cyclosporin + Mifepristone

Gravité: Contre-indiquée

Cyclosporin and Mifepristone: contraindicated interaction.

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Résumé

Mifepristone inhibits CYP3A4 and P-glycoprotein and can raise cyclosporine concentrations substantially. Higher cyclosporine levels increase nephrotoxicity, hypertension and neurotoxicity.

Ce que signifie cette interaction, en termes simples

Cyclosporin and Mifepristone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Cyclosporin belongs to Miscellaneous; Mifepristone belongs to Endocrine.

Niveau de preuve: Moderate

Pourquoi elle survient

CYP3A4 and P-gp inhibition raises cyclosporine exposure

Conduite à tenir

Avoid; if unavoidable, use the lowest cyclosporine dose with close trough monitoring and renal function checks.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Cyclosporin with Mifepristone?

MediHelp rates the interaction as contraindicated. Cyclosporin and Mifepristone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Mifepristone inhibits CYP3A4 and P-glycoprotein and can raise cyclosporine concentrations substantially. Higher cyclosporine levels increase nephrotoxicity, hypertension and neurotoxicity.

How serious is the interaction between Cyclosporin and Mifepristone?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid; if unavoidable, use the lowest cyclosporine dose with close trough monitoring and renal function checks.

What other medicines interact with Cyclosporin?

MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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