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MediHelp Référence médicamenteuse

Interactions médicamenteuses

Cisapride + Mifepristone

Gravité: Contre-indiquée

Cisapride and Mifepristone: contraindicated interaction.

Dernière mise à jour

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Résumé

Cisapride is metabolised by CYP3A4 and prolongs QT; mifepristone is a CYP3A4 inhibitor and can also lengthen the QT interval. Exposure to cisapride may increase and torsades de pointes becomes more likely.

Ce que signifie cette interaction, en termes simples

Cisapride and Mifepristone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Cisapride belongs to Gastrointestinal Tract; Mifepristone belongs to Endocrine.

Niveau de preuve: Moderate

Pourquoi elle survient

CYP3A4 inhibition plus additive QTc prolongation

Conduite à tenir

Do not co-administer.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Cisapride with Mifepristone?

MediHelp rates the interaction as contraindicated. Cisapride and Mifepristone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Cisapride is metabolised by CYP3A4 and prolongs QT; mifepristone is a CYP3A4 inhibitor and can also lengthen the QT interval. Exposure to cisapride may increase and torsades de pointes becomes more likely.

How serious is the interaction between Cisapride and Mifepristone?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer.

What other medicines interact with Cisapride?

MediHelp also lists interactions of Cisapride with, for example, Apomorphine, Artemether, Azithromycin. The full list is on the Cisapride page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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