Interactions médicamenteuses
Azathioprine + Ciltacabtagene autoleucel
Gravité: Majeure
Azathioprine and Ciltacabtagene autoleucel: major interaction.
Dernière mise à jour
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Résumé
Azathioprine may impair T-cell function and reduce CAR-T cell expansion and efficacy. It also increases the risk of infection during the cytopenic period after CAR-T therapy.
Ce que signifie cette interaction, en termes simples
Azathioprine and Ciltacabtagene autoleucel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Azathioprine belongs to Gastrointestinal Tract; Ciltacabtagene autoleucel belongs to Miscellaneous.
Pourquoi elle survient
Immunosuppressive antimetabolite activity against lymphocytes may reduce CAR-T cell expansion and persistence.
Conduite à tenir
Discontinue azathioprine before leukapheresis and infusion as directed by the treating center. Monitor for infection if it must continue.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Azathioprine
- Adenovirus types 4 and 7 live + Azathioprine Contre-indiquée
- Azathioprine + Bcg vaccine live Contre-indiquée
- Azathioprine + Febuxostat Contre-indiquée
- Azathioprine + Influenza virus vaccine quadrivalent intranasal Contre-indiquée
- Azathioprine + Measles mumps and rubella vaccine Contre-indiquée
- Azathioprine + Measles mumps and rubella vaccine live Contre-indiquée
Autres interactions de Ciltacabtagene autoleucel
Questions fréquentes
Can I take Azathioprine with Ciltacabtagene autoleucel?
MediHelp rates the interaction as major. Azathioprine and Ciltacabtagene autoleucel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Azathioprine may impair T-cell function and reduce CAR-T cell expansion and efficacy. It also increases the risk of infection during the cytopenic period after CAR-T therapy.
How serious is the interaction between Azathioprine and Ciltacabtagene autoleucel?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Discontinue azathioprine before leukapheresis and infusion as directed by the treating center. Monitor for infection if it must continue.
What other medicines interact with Azathioprine?
MediHelp also lists interactions of Azathioprine with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Febuxostat. The full list is on the Azathioprine page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
