Interactions médicamenteuses
Bcg intravesical live + Certolizumab pegol
Gravité: Contre-indiquée
Bcg intravesical live and Certolizumab pegol: contraindicated interaction.
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Résumé
Intravesical BCG is live Mycobacterium bovis. In patients on a TNF inhibitor, impaired granulomatous immunity may permit systemic BCG infection (BCGosis), and the antitumor response may be reduced.
Ce que signifie cette interaction, en termes simples
Bcg intravesical live and Certolizumab pegol are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Pourquoi elle survient
TNF is essential for granuloma formation and mycobacterial containment, so its inhibition allows BCG dissemination.
Conduite à tenir
Avoid intravesical BCG during certolizumab therapy and consider alternative bladder cancer treatment. If BCG is essential, discuss pausing certolizumab with the treating specialists.
Questions à poser à votre pharmacien
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Autres interactions de Certolizumab pegol
- Adenovirus types 4 and 7 live + Certolizumab pegol Contre-indiquée
- Bcg vaccine live + Certolizumab pegol Contre-indiquée
- Certolizumab pegol + Influenza virus vaccine quadrivalent intranasal Contre-indiquée
- Certolizumab pegol + Measles mumps and rubella vaccine Contre-indiquée
- Certolizumab pegol + Measles mumps and rubella vaccine live Contre-indiquée
- Certolizumab pegol + Measles mumps rubella and varicella vaccine live Contre-indiquée
Questions fréquentes
Can I take Bcg intravesical live with Certolizumab pegol?
MediHelp rates the interaction as contraindicated. Bcg intravesical live and Certolizumab pegol are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Intravesical BCG is live Mycobacterium bovis. In patients on a TNF inhibitor, impaired granulomatous immunity may permit systemic BCG infection (BCGosis), and the antitumor response may be reduced.
How serious is the interaction between Bcg intravesical live and Certolizumab pegol?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid intravesical BCG during certolizumab therapy and consider alternative bladder cancer treatment. If BCG is essential, discuss pausing certolizumab with the treating specialists.
What other medicines interact with Certolizumab pegol?
MediHelp also lists interactions of Certolizumab pegol with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Certolizumab pegol page.
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