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Interactions médicamenteuses

Bcg vaccine live + Certolizumab pegol

Gravité: Contre-indiquée

Bcg vaccine live and Certolizumab pegol: contraindicated interaction.

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Résumé

BCG vaccine contains live attenuated mycobacteria. TNF blockade may permit disseminated BCG infection and also weaken the vaccine response.

Ce que signifie cette interaction, en termes simples

Bcg vaccine live and Certolizumab pegol are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Niveau de preuve: Moderate

Pourquoi elle survient

TNF inhibition impairs granuloma formation and mycobacterial containment.

Conduite à tenir

Do not give BCG vaccine during certolizumab therapy. Vaccinate at least 4 weeks beforehand if needed.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Bcg vaccine live with Certolizumab pegol?

MediHelp rates the interaction as contraindicated. Bcg vaccine live and Certolizumab pegol are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. BCG vaccine contains live attenuated mycobacteria. TNF blockade may permit disseminated BCG infection and also weaken the vaccine response.

How serious is the interaction between Bcg vaccine live and Certolizumab pegol?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give BCG vaccine during certolizumab therapy. Vaccinate at least 4 weeks beforehand if needed.

What other medicines interact with Certolizumab pegol?

MediHelp also lists interactions of Certolizumab pegol with, for example, Adenovirus types 4 and 7 live, Bcg intravesical live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Certolizumab pegol page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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