Interactions médicamenteuses
Benzathine penicillin g + Ceftobiprole medocaril
Gravité: Mineure
Benzathine penicillin g and Ceftobiprole medocaril: minor interaction.
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Résumé
Ceftobiprole inhibits hepatic uptake transporters OATP1B1 and OATP1B3 and could raise exposure to substrates. Penicillin G is not a clinically important OATP substrate and has a wide therapeutic index, so a meaningful effect is not expected.
Ce que signifie cette interaction, en termes simples
Benzathine penicillin g and Ceftobiprole medocaril have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Pourquoi elle survient
Possible inhibition of OATP1B1/1B3-mediated uptake by ceftobiprole; relevance for penicillin G is theoretical.
Conduite à tenir
No dose adjustment is needed. Be aware of the potential effect and watch for penicillin adverse effects such as hypersensitivity or neurotoxicity in patients with renal impairment.
Questions à poser à votre pharmacien
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Autres interactions de Benzathine penicillin g
- Benzathine penicillin g + Cholera vaccine Modérée
- Benzathine penicillin g + Microbiota Modérée
- Benzathine penicillin g + Omadacycline Modérée
- Benzathine penicillin g + Sodium picosulfate / magnesium oxide / anhydrous citric acid Modérée
- Benzathine penicillin g + Vadadustat Modérée
- Amifampridine + Benzathine penicillin g Mineure
Questions fréquentes
Can I take Benzathine penicillin g with Ceftobiprole medocaril?
MediHelp rates the interaction as minor. Benzathine penicillin g and Ceftobiprole medocaril have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ceftobiprole inhibits hepatic uptake transporters OATP1B1 and OATP1B3 and could raise exposure to substrates. Penicillin G is not a clinically important OATP substrate and has a wide therapeutic index, so a meaningful effect is not expected.
How serious is the interaction between Benzathine penicillin g and Ceftobiprole medocaril?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Be aware of the potential effect and watch for penicillin adverse effects such as hypersensitivity or neurotoxicity in patients with renal impairment.
What other medicines interact with Benzathine penicillin g?
MediHelp also lists interactions of Benzathine penicillin g with, for example, Cholera vaccine, Microbiota, Omadacycline. The full list is on the Benzathine penicillin g page.
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