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Interactions médicamenteuses

Brimonidine + Rasagiline

Gravité: Contre-indiquée

Brimonidine and Rasagiline: contraindicated interaction.

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Résumé

Brimonidine labelling forbids use with MAO inhibitors, and rasagiline is an irreversible MAO-B inhibitor. Systemic absorption of the alpha-2 agonist could lead to unpredictable blood-pressure changes, and the effect on catecholamine handling is poorly characterised.

Ce que signifie cette interaction, en termes simples

Brimonidine and Rasagiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Brimonidine belongs to Miscellaneous; Rasagiline belongs to Central Nervous System.

Niveau de preuve: Low

Pourquoi elle survient

Uncertain: MAO inhibition may alter handling of circulating amines and potentiate systemic alpha-2 agonist cardiovascular effects

Conduite à tenir

Avoid brimonidine in patients taking rasagiline; use a different intraocular-pressure-lowering agent such as a prostaglandin analogue or beta-blocker where appropriate.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Brimonidine with Rasagiline?

MediHelp rates the interaction as contraindicated. Brimonidine and Rasagiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Brimonidine labelling forbids use with MAO inhibitors, and rasagiline is an irreversible MAO-B inhibitor. Systemic absorption of the alpha-2 agonist could lead to unpredictable blood-pressure changes, and the effect on catecholamine handling is poorly characterised.

How serious is the interaction between Brimonidine and Rasagiline?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid brimonidine in patients taking rasagiline; use a different intraocular-pressure-lowering agent such as a prostaglandin analogue or beta-blocker where appropriate.

What other medicines interact with Rasagiline?

MediHelp also lists interactions of Rasagiline with, for example, Atomoxetine, Bupropion-naltrexone, Bupropion. The full list is on the Rasagiline page.

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