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Interactions médicamenteuses

Clomipramine + Rasagiline

Gravité: Contre-indiquée

Clomipramine and Rasagiline: contraindicated interaction.

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Résumé

Rasagiline is an MAO-B inhibitor, and combining it with clomipramine carries a risk of serotonin syndrome and hypertensive reactions. Labeling advises a washout period between these drugs.

Ce que signifie cette interaction, en termes simples

Clomipramine and Rasagiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Clomipramine belongs to Central Nervous System; Rasagiline belongs to Central Nervous System.

Niveau de preuve: Moderate

Pourquoi elle survient

MAO inhibition combined with tricyclic serotonin and norepinephrine reuptake blockade increases monoamine levels.

Conduite à tenir

Do not co-administer; allow at least 14 days after stopping rasagiline before starting clomipramine, and an adequate washout of clomipramine before starting rasagiline.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Clomipramine with Rasagiline?

MediHelp rates the interaction as contraindicated. Clomipramine and Rasagiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Rasagiline is an MAO-B inhibitor, and combining it with clomipramine carries a risk of serotonin syndrome and hypertensive reactions. Labeling advises a washout period between these drugs.

How serious is the interaction between Clomipramine and Rasagiline?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; allow at least 14 days after stopping rasagiline before starting clomipramine, and an adequate washout of clomipramine before starting rasagiline.

What other medicines interact with Clomipramine?

MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.

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