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Interactions médicamenteuses

Deutetrabenazine + Rasagiline

Gravité: Contre-indiquée

Deutetrabenazine and Rasagiline: contraindicated interaction.

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Résumé

Deutetrabenazine is contraindicated with MAO inhibitors and within 14 days of stopping one. The combination may cause hypertension and excess monoaminergic effects.

Ce que signifie cette interaction, en termes simples

Deutetrabenazine and Rasagiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Deutetrabenazine belongs to Central Nervous System; Rasagiline belongs to Central Nervous System.

Niveau de preuve: Moderate

Pourquoi elle survient

Deutetrabenazine depletes vesicular monoamines, and with MAO inhibition the released monoamines are not degraded, leading to unstable sympathetic effects.

Conduite à tenir

Do not co-administer and keep a 14-day gap after stopping the MAO inhibitor. Consider another treatment for chorea or tardive dyskinesia.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Deutetrabenazine with Rasagiline?

MediHelp rates the interaction as contraindicated. Deutetrabenazine and Rasagiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Deutetrabenazine is contraindicated with MAO inhibitors and within 14 days of stopping one. The combination may cause hypertension and excess monoaminergic effects.

How serious is the interaction between Deutetrabenazine and Rasagiline?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer and keep a 14-day gap after stopping the MAO inhibitor. Consider another treatment for chorea or tardive dyskinesia.

What other medicines interact with Rasagiline?

MediHelp also lists interactions of Rasagiline with, for example, Atomoxetine, Brimonidine, Bupropion-naltrexone. The full list is on the Rasagiline page.

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