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Interactions médicamenteuses

Desvenlafaxine + Rasagiline

Gravité: Contre-indiquée

Desvenlafaxine and Rasagiline: contraindicated interaction.

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Résumé

Rasagiline inhibits monoamine oxidase and so reduces serotonin breakdown, while desvenlafaxine blocks serotonin and norepinephrine reuptake. Together this can precipitate serotonin syndrome, with agitation, hyperthermia, clonus and autonomic instability that may be fatal.

Ce que signifie cette interaction, en termes simples

Desvenlafaxine and Rasagiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Desvenlafaxine belongs to Central Nervous System; Rasagiline belongs to Central Nervous System.

Niveau de preuve: High

Pourquoi elle survient

Additive serotonergic activity: irreversible MAO-B inhibition (selectivity is lost at higher doses) plus monoamine reuptake inhibition

Conduite à tenir

Do not combine; allow at least 14 days after stopping the rasagiline before starting desvenlafaxine, and at least 14 days after stopping desvenlafaxine before starting the rasagiline.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Desvenlafaxine with Rasagiline?

MediHelp rates the interaction as contraindicated. Desvenlafaxine and Rasagiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Rasagiline inhibits monoamine oxidase and so reduces serotonin breakdown, while desvenlafaxine blocks serotonin and norepinephrine reuptake. Together this can precipitate serotonin syndrome, with agitation, hyperthermia, clonus and autonomic instability that may be fatal.

How serious is the interaction between Desvenlafaxine and Rasagiline?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; allow at least 14 days after stopping the rasagiline before starting desvenlafaxine, and at least 14 days after stopping desvenlafaxine before starting the rasagiline.

What other medicines interact with Desvenlafaxine?

MediHelp also lists interactions of Desvenlafaxine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Desvenlafaxine page.

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