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Interactions médicamenteuses

Bupropion-naltrexone + Rasagiline

Gravité: Contre-indiquée

Bupropion-naltrexone and Rasagiline: contraindicated interaction.

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Résumé

Rasagiline (an irreversible MAO-B inhibitor) slows catecholamine breakdown, while bupropion blocks reuptake of dopamine and noradrenaline. The combination can produce hypertensive crisis, agitation and seizures; labelling for bupropion prohibits concurrent MAOI therapy.

Ce que signifie cette interaction, en termes simples

Bupropion-naltrexone and Rasagiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Bupropion-naltrexone belongs to Miscellaneous; Rasagiline belongs to Central Nervous System.

Niveau de preuve: High

Pourquoi elle survient

MAO inhibition combined with dopamine and noradrenaline reuptake inhibition causes excess catecholamine activity

Conduite à tenir

Do not use together. Wait at least 14 days after stopping rasagiline before starting the other drug; allow at least a week after stopping bupropion before starting an MAOI.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Bupropion-naltrexone with Rasagiline?

MediHelp rates the interaction as contraindicated. Bupropion-naltrexone and Rasagiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Rasagiline (an irreversible MAO-B inhibitor) slows catecholamine breakdown, while bupropion blocks reuptake of dopamine and noradrenaline. The combination can produce hypertensive crisis, agitation and seizures; labelling for bupropion prohibits concurrent MAOI therapy.

How serious is the interaction between Bupropion-naltrexone and Rasagiline?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together. Wait at least 14 days after stopping rasagiline before starting the other drug; allow at least a week after stopping bupropion before starting an MAOI.

What other medicines interact with Bupropion-naltrexone?

MediHelp also lists interactions of Bupropion-naltrexone with, for example, Hydrocodone, Hydromorphone, Isocarboxazid. The full list is on the Bupropion-naltrexone page.

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