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Interactions médicamenteuses

Bupropion + Cefpirome

Gravité: Modérée

Bupropion and Cefpirome: moderate interaction.

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Résumé

Cefepime-class cephalosporins such as cefpirome can cause neurotoxicity and lower the seizure threshold, particularly in renal impairment. Together with bupropion, which also lowers the seizure threshold, the risk of seizures may be increased.

Ce que signifie cette interaction, en termes simples

Bupropion and Cefpirome can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Bupropion belongs to Central Nervous System; Cefpirome belongs to Anti Bacterial.

Niveau de preuve: Low

Pourquoi elle survient

Additive lowering of seizure threshold (cephalosporin GABA-A antagonism plus bupropion's proconvulsant effect).

Conduite à tenir

Keep the bupropion dose as low as possible and adjust cefpirome dose for renal function. Monitor for myoclonus, confusion or seizures.

Questions à poser à votre pharmacien

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Bupropion with Cefpirome?

MediHelp rates the interaction as moderate. Bupropion and Cefpirome can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cefepime-class cephalosporins such as cefpirome can cause neurotoxicity and lower the seizure threshold, particularly in renal impairment. Together with bupropion, which also lowers the seizure threshold, the risk of seizures may be increased.

How serious is the interaction between Bupropion and Cefpirome?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Keep the bupropion dose as low as possible and adjust cefpirome dose for renal function. Monitor for myoclonus, confusion or seizures.

What other medicines interact with Bupropion?

MediHelp also lists interactions of Bupropion with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Bupropion page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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