Aller au contenu
MediHelp
MediHelp Référence médicamenteuse

Interactions médicamenteuses

Bupropion + Selegiline

Gravité: Contre-indiquée

Bupropion and Selegiline: contraindicated interaction.

Dernière mise à jour

Réservé aux professionnels de santé — à titre de référence uniquement. Cette page est un bref résumé, pas un avis médical, et ne remplace ni la notice officielle ni le jugement clinique. Vérifiez toujours avant de prescrire ou de délivrer.

Le contenu clinique de cette page n'est disponible qu'en anglais.

Résumé

Selegiline (an MAO-B inhibitor that loses selectivity at higher or transdermal doses) slows catecholamine breakdown, while bupropion blocks reuptake of dopamine and noradrenaline. The combination can produce hypertensive crisis, agitation and seizures; labelling for bupropion prohibits concurrent MAOI therapy.

Ce que signifie cette interaction, en termes simples

Bupropion and Selegiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Bupropion belongs to Central Nervous System; Selegiline belongs to Central Nervous System.

Niveau de preuve: High

Pourquoi elle survient

MAO inhibition combined with dopamine and noradrenaline reuptake inhibition causes excess catecholamine activity

Conduite à tenir

Do not use together. Wait at least 14 days after stopping selegiline before starting the other drug; allow at least a week after stopping bupropion before starting an MAOI.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

Réservé aux membres Pro+

Débloquer la page complète

Créez un compte et lancez un essai Pro+ pour débloquer les conseils complets de prise en charge pour Bupropion et Selegiline, les notes complémentaires, le détail des données probantes et le vérificateur d'interactions pour une ordonnance complète.

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription
Créer un compte gratuit Se connecter

Essayez Pro+ gratuitement pendant 14 jours sur le web. Sans carte.

Questions fréquentes

Can I take Bupropion with Selegiline?

MediHelp rates the interaction as contraindicated. Bupropion and Selegiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Selegiline (an MAO-B inhibitor that loses selectivity at higher or transdermal doses) slows catecholamine breakdown, while bupropion blocks reuptake of dopamine and noradrenaline. The combination can produce hypertensive crisis, agitation and seizures; labelling for bupropion prohibits concurrent MAOI therapy.

How serious is the interaction between Bupropion and Selegiline?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together. Wait at least 14 days after stopping selegiline before starting the other drug; allow at least a week after stopping bupropion before starting an MAOI.

What other medicines interact with Bupropion?

MediHelp also lists interactions of Bupropion with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Bupropion page.

Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp

Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

Télécharger surApp Store Disponible surGoogle Play

Parcourir de A à Z · Interactions médicamenteuses

Télécharger l'app Se connecter