Interactions médicamenteuses
Butabarbital + Tinidazole
Gravité: Modérée
Butabarbital and Tinidazole: moderate interaction.
Dernière mise à jour
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Résumé
Barbiturates are enzyme inducers and may lower tinidazole concentrations, potentially reducing its antimicrobial effect. The effect is predicted from the related nitroimidazole metronidazole and from induction principles rather than extensively studied.
Ce que signifie cette interaction, en termes simples
Butabarbital and Tinidazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pourquoi elle survient
Barbiturate induction of hepatic CYP enzymes increases tinidazole metabolism.
Conduite à tenir
Monitor clinical response to tinidazole, particularly in serious infections. Consider a longer course or alternative therapy if response is inadequate.
Questions à poser à votre pharmacien
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Autres interactions de Tinidazole
- Disulfiram + Tinidazole Contre-indiquée
- Ethanol + Tinidazole Majeure
- Fexinidazole + Tinidazole Majeure
- Lopinavir + Tinidazole Majeure
- Nilotinib + Tinidazole Majeure
- Ritonavir + Tinidazole Majeure
Questions fréquentes
Can I take Butabarbital with Tinidazole?
MediHelp rates the interaction as moderate. Butabarbital and Tinidazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Barbiturates are enzyme inducers and may lower tinidazole concentrations, potentially reducing its antimicrobial effect. The effect is predicted from the related nitroimidazole metronidazole and from induction principles rather than extensively studied.
How serious is the interaction between Butabarbital and Tinidazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response to tinidazole, particularly in serious infections. Consider a longer course or alternative therapy if response is inadequate.
What other medicines interact with Tinidazole?
MediHelp also lists interactions of Tinidazole with, for example, Disulfiram, Ethanol, Fexinidazole. The full list is on the Tinidazole page.
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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
