Aller au contenu
MediHelp
MediHelp Référence médicamenteuse

Interactions médicamenteuses

Caplacizumab + Dabigatran etexilate

Gravité: Majeure

Caplacizumab and Dabigatran etexilate: major interaction.

Dernière mise à jour

Réservé aux professionnels de santé — à titre de référence uniquement. Cette page est un bref résumé, pas un avis médical, et ne remplace ni la notice officielle ni le jugement clinique. Vérifiez toujours avant de prescrire ou de délivrer.

Le contenu clinique de cette page n'est disponible qu'en anglais.

Résumé

Caplacizumab blocks von Willebrand factor-platelet binding and impairs primary hemostasis, and dabigatran adds anticoagulant effect. Together they increase the risk of serious bleeding.

Ce que signifie cette interaction, en termes simples

Caplacizumab and Dabigatran etexilate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Caplacizumab belongs to Cardiovascular; Dabigatran etexilate belongs to Cardiovascular.

Niveau de preuve: Moderate

Pourquoi elle survient

Additive hemostatic impairment: antiplatelet-like vWF inhibition plus direct thrombin inhibition.

Conduite à tenir

Avoid concurrent use where possible; if anticoagulation is essential, monitor closely for bleeding and consider holding dabigatran during caplacizumab treatment. Withhold both before invasive procedures per labeling.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

Réservé aux membres Pro+

Débloquer la page complète

Créez un compte et lancez un essai Pro+ pour débloquer les conseils complets de prise en charge pour Caplacizumab et Dabigatran etexilate, les notes complémentaires, le détail des données probantes et le vérificateur d'interactions pour une ordonnance complète.

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription
Créer un compte gratuit Se connecter

Essayez Pro+ gratuitement pendant 14 jours sur le web. Sans carte.

Questions fréquentes

Can I take Caplacizumab with Dabigatran etexilate?

MediHelp rates the interaction as major. Caplacizumab and Dabigatran etexilate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Caplacizumab blocks von Willebrand factor-platelet binding and impairs primary hemostasis, and dabigatran adds anticoagulant effect. Together they increase the risk of serious bleeding.

How serious is the interaction between Caplacizumab and Dabigatran etexilate?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where possible; if anticoagulation is essential, monitor closely for bleeding and consider holding dabigatran during caplacizumab treatment. Withhold both before invasive procedures per labeling.

What other medicines interact with Dabigatran etexilate?

MediHelp also lists interactions of Dabigatran etexilate with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Dabigatran etexilate page.

Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp

Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

Télécharger surApp Store Disponible surGoogle Play

Parcourir de A à Z · Interactions médicamenteuses

Télécharger l'app Se connecter