Interactions médicamenteuses
Clarithromycin + Eletriptan
Gravité: Contre-indiquée
Clarithromycin and Eletriptan: contraindicated interaction.
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Résumé
Clarithromycin is a strong CYP3A4 inhibitor, and eletriptan is cleared largely by CYP3A4. Raised eletriptan exposure can lead to excessive eletriptan effect, including vasoconstriction and coronary spasm.
Ce que signifie cette interaction, en termes simples
Clarithromycin and Eletriptan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Clarithromycin belongs to Anti Bacterial; Eletriptan belongs to Central Nervous System.
Pourquoi elle survient
CYP3A4 inhibition by clarithromycin reduces first-pass and systemic clearance of eletriptan
Conduite à tenir
Do not combine; choose an alternative to clarithromycin.
Questions à poser à votre pharmacien
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Autres interactions de Clarithromycin
- Astemizole + Clarithromycin Contre-indiquée
- Avanafil + Clarithromycin Contre-indiquée
- Cisapride + Clarithromycin Contre-indiquée
- Clarithromycin + Colchicine Contre-indiquée
- Clarithromycin + Conivaptan Contre-indiquée
- Clarithromycin + Dihydroergotamine Contre-indiquée
Autres interactions de Eletriptan
- Almotriptan + Eletriptan Contre-indiquée
- Atazanavir + Eletriptan Contre-indiquée
- Ceritinib + Eletriptan Contre-indiquée
- Cobicistat + Eletriptan Contre-indiquée
- Conivaptan + Eletriptan Contre-indiquée
- Darunavir + Eletriptan Contre-indiquée
Questions fréquentes
Can I take Clarithromycin with Eletriptan?
MediHelp rates the interaction as contraindicated. Clarithromycin and Eletriptan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Clarithromycin is a strong CYP3A4 inhibitor, and eletriptan is cleared largely by CYP3A4. Raised eletriptan exposure can lead to excessive eletriptan effect, including vasoconstriction and coronary spasm.
How serious is the interaction between Clarithromycin and Eletriptan?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; choose an alternative to clarithromycin.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
