Interactions médicamenteuses
Chenodeoxycholic acid + Phenobarbitone
Gravité: Modérée
Chenodeoxycholic acid and Phenobarbitone: moderate interaction.
Dernière mise à jour
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Résumé
Phenobarbital can induce HMG-CoA reductase and bile acid synthesis, which may counteract the intended suppression of abnormal bile acid production by chenodeoxycholic acid. Therapeutic effect may be reduced.
Ce que signifie cette interaction, en termes simples
Chenodeoxycholic acid and Phenobarbitone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chenodeoxycholic acid belongs to Gastrointestinal Tract; Phenobarbitone belongs to Central Nervous System.
Pourquoi elle survient
Enzyme induction by phenobarbital increases cholesterol and bile acid synthesis, opposing chenodeoxycholic acid feedback inhibition.
Conduite à tenir
Monitor urinary or serum bile alcohols and adjust the chenodeoxycholic acid dose as needed. Consider a non-inducing anticonvulsant if appropriate.
Questions à poser à votre pharmacien
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Autres interactions de Chenodeoxycholic acid
Autres interactions de Phenobarbitone
- Cabotegravir + Phenobarbitone Contre-indiquée
- Doravirine + Phenobarbitone Contre-indiquée
- Isavuconazole + Phenobarbitone Contre-indiquée
- Darolutamide + Phenobarbitone Majeure
- Finerenone + Phenobarbitone Majeure
- Ivacaftor + Phenobarbitone Majeure
Questions fréquentes
Can I take Chenodeoxycholic acid with Phenobarbitone?
MediHelp rates the interaction as moderate. Chenodeoxycholic acid and Phenobarbitone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenobarbital can induce HMG-CoA reductase and bile acid synthesis, which may counteract the intended suppression of abnormal bile acid production by chenodeoxycholic acid. Therapeutic effect may be reduced.
How serious is the interaction between Chenodeoxycholic acid and Phenobarbitone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor urinary or serum bile alcohols and adjust the chenodeoxycholic acid dose as needed. Consider a non-inducing anticonvulsant if appropriate.
What other medicines interact with Chenodeoxycholic acid?
MediHelp also lists interactions of Chenodeoxycholic acid with, for example, Cyclosporin, Sirolimus, Aluminum hydroxide. The full list is on the Chenodeoxycholic acid page.
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