Interactions médicamenteuses
Chloramphenicol + Tisotumab vedotin
Gravité: Modérée
Chloramphenicol and Tisotumab vedotin: moderate interaction.
Dernière mise à jour
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Résumé
MMAE released from tisotumab vedotin is a CYP3A4 substrate, so chloramphenicol may increase exposure and toxicities such as neuropathy, ocular effects and neutropenia.
Ce que signifie cette interaction, en termes simples
Chloramphenicol and Tisotumab vedotin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chloramphenicol belongs to Anti Bacterial; Tisotumab vedotin belongs to Oncology.
Pourquoi elle survient
CYP3A4 inhibition by chloramphenicol may reduce MMAE clearance.
Conduite à tenir
Monitor for neuropathy, ocular toxicity and cytopenias. Prefer a non-inhibiting antibiotic where possible.
Questions à poser à votre pharmacien
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Autres interactions de Chloramphenicol
Autres interactions de Tisotumab vedotin
Questions fréquentes
Can I take Chloramphenicol with Tisotumab vedotin?
MediHelp rates the interaction as moderate. Chloramphenicol and Tisotumab vedotin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. MMAE released from tisotumab vedotin is a CYP3A4 substrate, so chloramphenicol may increase exposure and toxicities such as neuropathy, ocular effects and neutropenia.
How serious is the interaction between Chloramphenicol and Tisotumab vedotin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for neuropathy, ocular toxicity and cytopenias. Prefer a non-inhibiting antibiotic where possible.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
