Interactions médicamenteuses
Itraconazole + Tisotumab vedotin
Gravité: Modérée
Itraconazole and Tisotumab vedotin: moderate interaction.
Dernière mise à jour
Réservé aux professionnels de santé — à titre de référence uniquement. Cette page est un bref résumé, pas un avis médical, et ne remplace ni la notice officielle ni le jugement clinique. Vérifiez toujours avant de prescrire ou de délivrer.
Le contenu clinique de cette page n'est disponible qu'en anglais.
Résumé
Itraconazole may increase unconjugated MMAE exposure from tisotumab vedotin, which may worsen adverse effects such as neutropenia and neuropathy.
Ce que signifie cette interaction, en termes simples
Itraconazole and Tisotumab vedotin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Itraconazole belongs to Anti Fungals; Tisotumab vedotin belongs to Oncology.
Pourquoi elle survient
Strong CYP3A4 inhibition reduces the metabolism of MMAE.
Conduite à tenir
Monitor for adverse reactions such as neutropenia and neuropathy during co-therapy, and manage them by dose interruption or modification.
Questions à poser à votre pharmacien
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Réservé aux membres Pro+
Débloquer la page complète
Créez un compte et lancez un essai Pro+ pour débloquer les conseils complets de prise en charge pour Itraconazole et Tisotumab vedotin, les notes complémentaires, le détail des données probantes et le vérificateur d'interactions pour une ordonnance complète.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Essayez Pro+ gratuitement pendant 7 jours sur le web. Sans carte.
Autres interactions de Itraconazole
- Alfuzosin + Itraconazole Contre-indiquée
- Alprazolam + Itraconazole Contre-indiquée
- Avanafil + Itraconazole Contre-indiquée
- Conivaptan + Itraconazole Contre-indiquée
- Dihydroergotamine intranasal + Itraconazole Contre-indiquée
- Dihydroergotamine + Itraconazole Contre-indiquée
Autres interactions de Tisotumab vedotin
Questions fréquentes
Can I take Itraconazole with Tisotumab vedotin?
MediHelp rates the interaction as moderate. Itraconazole and Tisotumab vedotin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Itraconazole may increase unconjugated MMAE exposure from tisotumab vedotin, which may worsen adverse effects such as neutropenia and neuropathy.
How serious is the interaction between Itraconazole and Tisotumab vedotin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for adverse reactions such as neutropenia and neuropathy during co-therapy, and manage them by dose interruption or modification.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
