Interactions médicamenteuses
Ketoconazole + Tisotumab vedotin
Gravité: Modérée
Ketoconazole and Tisotumab vedotin: moderate interaction.
Dernière mise à jour
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Résumé
Ketoconazole may increase exposure to unconjugated MMAE, the cytotoxic payload of tisotumab vedotin, raising the risk of adverse effects such as neuropathy, ocular toxicity and neutropenia.
Ce que signifie cette interaction, en termes simples
Ketoconazole and Tisotumab vedotin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ketoconazole belongs to Anti Fungals; Tisotumab vedotin belongs to Oncology.
Pourquoi elle survient
Strong CYP3A4 inhibition reduces MMAE clearance.
Conduite à tenir
Monitor closely for adverse reactions during concurrent use, particularly neuropathy and neutropenia.
Questions à poser à votre pharmacien
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Autres interactions de Ketoconazole
- Alfuzosin + Ketoconazole Contre-indiquée
- Alprazolam + Ketoconazole Contre-indiquée
- Avanafil + Ketoconazole Contre-indiquée
- Conivaptan + Ketoconazole Contre-indiquée
- Dihydroergotamine intranasal + Ketoconazole Contre-indiquée
- Dihydroergotamine + Ketoconazole Contre-indiquée
Autres interactions de Tisotumab vedotin
Questions fréquentes
Can I take Ketoconazole with Tisotumab vedotin?
MediHelp rates the interaction as moderate. Ketoconazole and Tisotumab vedotin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ketoconazole may increase exposure to unconjugated MMAE, the cytotoxic payload of tisotumab vedotin, raising the risk of adverse effects such as neuropathy, ocular toxicity and neutropenia.
How serious is the interaction between Ketoconazole and Tisotumab vedotin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor closely for adverse reactions during concurrent use, particularly neuropathy and neutropenia.
What other medicines interact with Ketoconazole?
MediHelp also lists interactions of Ketoconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Ketoconazole page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
