Interactions médicamenteuses
Clarithromycin + Tisotumab vedotin
Gravité: Modérée
Clarithromycin and Tisotumab vedotin: moderate interaction.
Dernière mise à jour
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Résumé
The cytotoxic payload MMAE from tisotumab vedotin is a CYP3A4 substrate. A strong inhibitor like clarithromycin may raise MMAE exposure and increase toxicity, including neuropathy, neutropenia and ocular effects.
Ce que signifie cette interaction, en termes simples
Clarithromycin and Tisotumab vedotin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clarithromycin belongs to Anti Bacterial; Tisotumab vedotin belongs to Oncology.
Pourquoi elle survient
Clarithromycin inhibits CYP3A4 metabolism of MMAE.
Conduite à tenir
Consider a non-CYP3A4-inhibiting antibiotic. If combined, monitor for adverse reactions of tisotumab vedotin.
Questions à poser à votre pharmacien
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Autres interactions de Clarithromycin
- Astemizole + Clarithromycin Contre-indiquée
- Avanafil + Clarithromycin Contre-indiquée
- Cisapride + Clarithromycin Contre-indiquée
- Clarithromycin + Colchicine Contre-indiquée
- Clarithromycin + Conivaptan Contre-indiquée
- Clarithromycin + Dihydroergotamine Contre-indiquée
Autres interactions de Tisotumab vedotin
Questions fréquentes
Can I take Clarithromycin with Tisotumab vedotin?
MediHelp rates the interaction as moderate. Clarithromycin and Tisotumab vedotin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The cytotoxic payload MMAE from tisotumab vedotin is a CYP3A4 substrate. A strong inhibitor like clarithromycin may raise MMAE exposure and increase toxicity, including neuropathy, neutropenia and ocular effects.
How serious is the interaction between Clarithromycin and Tisotumab vedotin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider a non-CYP3A4-inhibiting antibiotic. If combined, monitor for adverse reactions of tisotumab vedotin.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
