Interactions médicamenteuses
Mifepristone + Tisotumab vedotin
Gravité: Modérée
Mifepristone and Tisotumab vedotin: moderate interaction.
Dernière mise à jour
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Résumé
The cytotoxic payload MMAE of tisotumab vedotin is a CYP3A4 substrate, and a strong CYP3A4 inhibitor may increase its exposure. This could worsen toxicities such as neutropenia and neuropathy.
Ce que signifie cette interaction, en termes simples
Mifepristone and Tisotumab vedotin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mifepristone belongs to Endocrine; Tisotumab vedotin belongs to Oncology.
Pourquoi elle survient
Mifepristone inhibits CYP3A4, reducing clearance of unconjugated MMAE released from the antibody-drug conjugate.
Conduite à tenir
Monitor for signs of tisotumab vedotin toxicity, including neutropenia, neuropathy and ocular effects. Consider an alternative to mifepristone when feasible.
Questions à poser à votre pharmacien
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Autres interactions de Mifepristone
- Apixaban + Mifepristone Contre-indiquée
- Argatroban + Mifepristone Contre-indiquée
- Cisapride + Mifepristone Contre-indiquée
- Cortisone + Mifepristone Contre-indiquée
- Cyclosporin + Mifepristone Contre-indiquée
- Dabigatran etexilate + Mifepristone Contre-indiquée
Autres interactions de Tisotumab vedotin
Questions fréquentes
Can I take Mifepristone with Tisotumab vedotin?
MediHelp rates the interaction as moderate. Mifepristone and Tisotumab vedotin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The cytotoxic payload MMAE of tisotumab vedotin is a CYP3A4 substrate, and a strong CYP3A4 inhibitor may increase its exposure. This could worsen toxicities such as neutropenia and neuropathy.
How serious is the interaction between Mifepristone and Tisotumab vedotin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of tisotumab vedotin toxicity, including neutropenia, neuropathy and ocular effects. Consider an alternative to mifepristone when feasible.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
