Interactions médicamenteuses
Posaconazole + Tisotumab vedotin
Gravité: Modérée
Posaconazole and Tisotumab vedotin: moderate interaction.
Dernière mise à jour
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Résumé
The cytotoxic payload of tisotumab vedotin, MMAE, is metabolized by CYP3A4, so a strong inhibitor like posaconazole may increase unconjugated MMAE exposure. This could heighten toxicities such as neutropenia, neuropathy and ocular events.
Ce que signifie cette interaction, en termes simples
Posaconazole and Tisotumab vedotin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Posaconazole belongs to Anti Fungals; Tisotumab vedotin belongs to Oncology.
Pourquoi elle survient
Strong CYP3A4 inhibition by posaconazole reduces the clearance of released MMAE.
Conduite à tenir
Monitor closely for signs of MMAE toxicity, including blood counts and neuropathy, during concomitant use. Consider an alternative antifungal where feasible.
Questions à poser à votre pharmacien
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Autres interactions de Posaconazole
- Artemether + Posaconazole Contre-indiquée
- Avanafil + Posaconazole Contre-indiquée
- Cobimetinib + Posaconazole Contre-indiquée
- Conivaptan + Posaconazole Contre-indiquée
- Dihydroergotamine intranasal + Posaconazole Contre-indiquée
- Dihydroergotamine + Posaconazole Contre-indiquée
Autres interactions de Tisotumab vedotin
Questions fréquentes
Can I take Posaconazole with Tisotumab vedotin?
MediHelp rates the interaction as moderate. Posaconazole and Tisotumab vedotin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The cytotoxic payload of tisotumab vedotin, MMAE, is metabolized by CYP3A4, so a strong inhibitor like posaconazole may increase unconjugated MMAE exposure. This could heighten toxicities such as neutropenia, neuropathy and ocular events.
How serious is the interaction between Posaconazole and Tisotumab vedotin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor closely for signs of MMAE toxicity, including blood counts and neuropathy, during concomitant use. Consider an alternative antifungal where feasible.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
