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Interactions médicamenteuses

Chlorpromazine + Glycopyrrolate

Gravité: Modérée

Chlorpromazine and Glycopyrrolate: moderate interaction.

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Résumé

Chlorpromazine has anticholinergic properties that add to those of glycopyrrolate. This may cause dry mouth, constipation, urinary retention, blurred vision, tachycardia and confusion, and in severe cases reduced gut motility or ileus.

Ce que signifie cette interaction, en termes simples

Chlorpromazine and Glycopyrrolate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Chlorpromazine belongs to Central Nervous System; Glycopyrrolate belongs to Respiratory.

Niveau de preuve: Moderate

Pourquoi elle survient

Additive antimuscarinic (anticholinergic) pharmacodynamic effects.

Conduite à tenir

Monitor for anticholinergic adverse effects, especially in older patients, and for constipation or urinary retention. Reduce the dose of one agent or choose an alternative if symptoms become troublesome.

Questions à poser à votre pharmacien

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Chlorpromazine with Glycopyrrolate?

MediHelp rates the interaction as moderate. Chlorpromazine and Glycopyrrolate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorpromazine has anticholinergic properties that add to those of glycopyrrolate. This may cause dry mouth, constipation, urinary retention, blurred vision, tachycardia and confusion, and in severe cases reduced gut motility or ileus.

How serious is the interaction between Chlorpromazine and Glycopyrrolate?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic adverse effects, especially in older patients, and for constipation or urinary retention. Reduce the dose of one agent or choose an alternative if symptoms become troublesome.

What other medicines interact with Chlorpromazine?

MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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