Interactions médicamenteuses
Amitriptyline + Glycopyrrolate
Gravité: Modérée
Amitriptyline and Glycopyrrolate: moderate interaction.
Dernière mise à jour
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Résumé
Both drugs have anticholinergic activity, so combined use can cause dry mouth, constipation, urinary retention, blurred vision and tachycardia. In susceptible patients, such as older adults, confusion, ileus or heat intolerance may occur.
Ce que signifie cette interaction, en termes simples
Amitriptyline and Glycopyrrolate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amitriptyline belongs to Central Nervous System; Glycopyrrolate belongs to Respiratory.
Pourquoi elle survient
Additive antimuscarinic effects from muscarinic receptor blockade.
Conduite à tenir
Monitor for anticholinergic toxicity, especially in older patients or those with glaucoma, urinary retention or constipation. Reduce doses or select non-anticholinergic alternatives if effects are troublesome.
Questions à poser à votre pharmacien
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Autres interactions de Amitriptyline
- Amitriptyline + Isocarboxazid Contre-indiquée
- Amitriptyline + Methylene blue Contre-indiquée
- Amitriptyline + Phenelzine Contre-indiquée
- Amitriptyline + Pimozide Contre-indiquée
- Amitriptyline + Procarbazine Contre-indiquée
- Amitriptyline + Safinamide Contre-indiquée
Autres interactions de Glycopyrrolate
- Glycopyrrolate + Potassium chloride Majeure
- Atropine + Glycopyrrolate Modérée
- Bethanechol + Glycopyrrolate Modérée
- Chlorpromazine + Glycopyrrolate Modérée
- Clomipramine + Glycopyrrolate Modérée
- Clozapine + Glycopyrrolate Modérée
Questions fréquentes
Can I take Amitriptyline with Glycopyrrolate?
MediHelp rates the interaction as moderate. Amitriptyline and Glycopyrrolate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have anticholinergic activity, so combined use can cause dry mouth, constipation, urinary retention, blurred vision and tachycardia. In susceptible patients, such as older adults, confusion, ileus or heat intolerance may occur.
How serious is the interaction between Amitriptyline and Glycopyrrolate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity, especially in older patients or those with glaucoma, urinary retention or constipation. Reduce doses or select non-anticholinergic alternatives if effects are troublesome.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
