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Interactions médicamenteuses

Clomipramine + Glycopyrrolate

Gravité: Modérée

Clomipramine and Glycopyrrolate: moderate interaction.

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Résumé

Both drugs have anticholinergic activity, so combined use may worsen dry mouth, constipation, urinary retention, blurred vision and tachycardia. Anticholinergic burden is especially important in older patients.

Ce que signifie cette interaction, en termes simples

Clomipramine and Glycopyrrolate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Clomipramine belongs to Central Nervous System; Glycopyrrolate belongs to Respiratory.

Niveau de preuve: Moderate

Pourquoi elle survient

Additive antimuscarinic effects at peripheral and central cholinergic receptors.

Conduite à tenir

Monitor for anticholinergic effects such as urinary retention, ileus and heat intolerance. Reduce the dose of one drug or choose an alternative if effects are troublesome.

Questions à poser à votre pharmacien

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Clomipramine with Glycopyrrolate?

MediHelp rates the interaction as moderate. Clomipramine and Glycopyrrolate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have anticholinergic activity, so combined use may worsen dry mouth, constipation, urinary retention, blurred vision and tachycardia. Anticholinergic burden is especially important in older patients.

How serious is the interaction between Clomipramine and Glycopyrrolate?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic effects such as urinary retention, ileus and heat intolerance. Reduce the dose of one drug or choose an alternative if effects are troublesome.

What other medicines interact with Clomipramine?

MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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