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Interactions médicamenteuses

Bosentan + Cholic acid

Gravité: Majeure

Bosentan and Cholic acid: major interaction.

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Résumé

Bosentan inhibits the bile salt export pump, which can cause accumulation of bile salts in hepatocytes. Together with cholic acid, this may worsen liver injury.

Ce que signifie cette interaction, en termes simples

Bosentan and Cholic acid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Bosentan belongs to Miscellaneous; Cholic acid belongs to Gastrointestinal Tract.

Niveau de preuve: Moderate

Pourquoi elle survient

Bosentan inhibits BSEP, impairing biliary bile salt efflux.

Conduite à tenir

Avoid the combination when possible; if used, monitor serum transaminases and bilirubin frequently and stop if liver injury develops.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Bosentan with Cholic acid?

MediHelp rates the interaction as major. Bosentan and Cholic acid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Bosentan inhibits the bile salt export pump, which can cause accumulation of bile salts in hepatocytes. Together with cholic acid, this may worsen liver injury.

How serious is the interaction between Bosentan and Cholic acid?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination when possible; if used, monitor serum transaminases and bilirubin frequently and stop if liver injury develops.

What other medicines interact with Bosentan?

MediHelp also lists interactions of Bosentan with, for example, Cyclosporin, Cyclosporine, Glyburide. The full list is on the Bosentan page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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