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Interactions médicamenteuses

Cholic acid + Ketoconazole

Gravité: Majeure

Cholic acid and Ketoconazole: major interaction.

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Résumé

Ketoconazole may inhibit the bile salt export pump, which cholic acid therapy depends on for hepatic bile salt excretion. Accumulation of conjugated bile salts in hepatocytes can cause liver injury.

Ce que signifie cette interaction, en termes simples

Cholic acid and Ketoconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Cholic acid belongs to Gastrointestinal Tract; Ketoconazole belongs to Anti Fungals.

Niveau de preuve: Moderate

Pourquoi elle survient

Inhibition of the bile salt efflux pump (BSEP) reduces hepatic bile salt elimination.

Conduite à tenir

Avoid the combination where possible; if it is necessary, monitor serum transaminases and bilirubin regularly and stop cholic acid if liver injury develops.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Cholic acid with Ketoconazole?

MediHelp rates the interaction as major. Cholic acid and Ketoconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ketoconazole may inhibit the bile salt export pump, which cholic acid therapy depends on for hepatic bile salt excretion. Accumulation of conjugated bile salts in hepatocytes can cause liver injury.

How serious is the interaction between Cholic acid and Ketoconazole?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; if it is necessary, monitor serum transaminases and bilirubin regularly and stop cholic acid if liver injury develops.

What other medicines interact with Ketoconazole?

MediHelp also lists interactions of Ketoconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Ketoconazole page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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