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Interactions médicamenteuses

Cholic acid + Glyburide

Gravité: Majeure

Cholic acid and Glyburide: major interaction.

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Résumé

Glyburide inhibits the bile salt export pump and may impair biliary excretion of bile acids. In patients taking cholic acid, this may promote hepatic accumulation of bile salts and liver injury.

Ce que signifie cette interaction, en termes simples

Cholic acid and Glyburide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Cholic acid belongs to Gastrointestinal Tract; Glyburide belongs to Endocrine.

Niveau de preuve: Moderate

Pourquoi elle survient

Inhibition of the hepatic bile salt export pump (BSEP) by glyburide reduces bile acid efflux.

Conduite à tenir

Avoid the combination if possible and choose another antidiabetic agent. If it is necessary, monitor serum transaminases and bilirubin regularly.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Cholic acid with Glyburide?

MediHelp rates the interaction as major. Cholic acid and Glyburide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Glyburide inhibits the bile salt export pump and may impair biliary excretion of bile acids. In patients taking cholic acid, this may promote hepatic accumulation of bile salts and liver injury.

How serious is the interaction between Cholic acid and Glyburide?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible and choose another antidiabetic agent. If it is necessary, monitor serum transaminases and bilirubin regularly.

What other medicines interact with Glyburide?

MediHelp also lists interactions of Glyburide with, for example, Bosentan, Ciprofloxacin, Clarithromycin. The full list is on the Glyburide page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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