Aller au contenu
MediHelp
MediHelp Référence médicamenteuse

Interactions médicamenteuses

Cholic acid + Mifepristone

Gravité: Majeure

Cholic acid and Mifepristone: major interaction.

Dernière mise à jour

Réservé aux professionnels de santé — à titre de référence uniquement. Cette page est un bref résumé, pas un avis médical, et ne remplace ni la notice officielle ni le jugement clinique. Vérifiez toujours avant de prescrire ou de délivrer.

Le contenu clinique de cette page n'est disponible qu'en anglais.

Résumé

Mifepristone inhibits the bile salt export pump, which can cause conjugated bile salts to accumulate in hepatocytes. With cholic acid this may worsen liver injury or cholestasis.

Ce que signifie cette interaction, en termes simples

Cholic acid and Mifepristone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Cholic acid belongs to Gastrointestinal Tract; Mifepristone belongs to Endocrine.

Niveau de preuve: Moderate

Pourquoi elle survient

Inhibition of the bile salt export pump (BSEP) by mifepristone reduces biliary excretion of bile acids.

Conduite à tenir

Avoid concomitant use where possible. If necessary, monitor serum transaminases and bilirubin regularly and stop cholic acid if liver injury develops.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

Réservé aux membres Pro+

Débloquer la page complète

Créez un compte et lancez un essai Pro+ pour débloquer les conseils complets de prise en charge pour Cholic acid et Mifepristone, les notes complémentaires, le détail des données probantes et le vérificateur d'interactions pour une ordonnance complète.

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription
Créer un compte gratuit Se connecter

Essayez Pro+ gratuitement pendant 14 jours sur le web. Sans carte.

Questions fréquentes

Can I take Cholic acid with Mifepristone?

MediHelp rates the interaction as major. Cholic acid and Mifepristone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Mifepristone inhibits the bile salt export pump, which can cause conjugated bile salts to accumulate in hepatocytes. With cholic acid this may worsen liver injury or cholestasis.

How serious is the interaction between Cholic acid and Mifepristone?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use where possible. If necessary, monitor serum transaminases and bilirubin regularly and stop cholic acid if liver injury develops.

What other medicines interact with Mifepristone?

MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.

Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp

Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

Télécharger surApp Store Disponible surGoogle Play

Parcourir de A à Z · Interactions médicamenteuses

Télécharger l'app Se connecter