Interactions médicamenteuses
Fluvoxamine + Tizanidine
Gravité: Contre-indiquée
Fluvoxamine and Tizanidine: contraindicated interaction.
Dernière mise à jour Sources: US FDA label
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Résumé
Fluvoxamine markedly raises tizanidine concentrations, producing severe hypotension, bradycardia, profound sedation and psychomotor impairment. Tizanidine labeling contraindicates concomitant use with strong CYP1A2 inhibitors such as fluvoxamine. The effect is large and well documented.
Ce que signifie cette interaction, en termes simples
Fluvoxamine and Tizanidine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Fluvoxamine belongs to Central Nervous System; Tizanidine belongs to Musculoskeletal.
Pourquoi elle survient
Fluvoxamine is a potent CYP1A2 inhibitor and blocks the principal clearance pathway of tizanidine, causing a large increase in exposure.
Conduite à tenir
Do not combine. Use a different antispasticity or muscle-relaxant agent such as baclofen, or an antidepressant that does not strongly inhibit CYP1A2 (for example sertraline or escitalopram).
Questions à poser à votre pharmacien
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Références
Autres interactions de Tizanidine
- Ciprofloxacin + Tizanidine Contre-indiquée
- Pefloxacin + Tizanidine Contre-indiquée
- Pipemidic acid + Tizanidine Contre-indiquée
- Benzhydrocodone / acetaminophen + Tizanidine Majeure
- Brexanolone + Tizanidine Majeure
- Buprenorphine long-acting + Tizanidine Majeure
Autres interactions de Fluvoxamine
- Agomelatine + Fluvoxamine Contre-indiquée
- Alosetron + Fluvoxamine Contre-indiquée
- Fezolinetant + Fluvoxamine Contre-indiquée
- Fluvoxamine + Isocarboxazid Contre-indiquée
- Fluvoxamine + Mavacamten Contre-indiquée
- Fluvoxamine + Methylene blue Contre-indiquée
Questions fréquentes
Can I take Fluvoxamine with Tizanidine?
MediHelp rates the interaction as contraindicated. Fluvoxamine and Tizanidine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Fluvoxamine markedly raises tizanidine concentrations, producing severe hypotension, bradycardia, profound sedation and psychomotor impairment. Tizanidine labeling contraindicates concomitant use with strong CYP1A2 inhibitors such as fluvoxamine. The effect is large and well documented.
How serious is the interaction between Fluvoxamine and Tizanidine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine. Use a different antispasticity or muscle-relaxant agent such as baclofen, or an antidepressant that does not strongly inhibit CYP1A2 (for example sertraline or escitalopram).
What other medicines interact with Tizanidine?
MediHelp also lists interactions of Tizanidine with, for example, Ciprofloxacin, Pefloxacin, Pipemidic acid. The full list is on the Tizanidine page.
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