Interactions médicamenteuses
Pefloxacin + Tizanidine
Gravité: Contre-indiquée
Pefloxacin and Tizanidine: contraindicated interaction.
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Résumé
Pefloxacin inhibits CYP1A2, the main enzyme clearing tizanidine, so tizanidine levels can rise markedly. This can cause severe hypotension, bradycardia and profound sedation, as seen with the related drug ciprofloxacin.
Ce que signifie cette interaction, en termes simples
Pefloxacin and Tizanidine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Pefloxacin belongs to Anti Bacterial; Tizanidine belongs to Musculoskeletal.
Pourquoi elle survient
Inhibition of CYP1A2 by pefloxacin reduces tizanidine clearance.
Conduite à tenir
Avoid the combination and use an antibiotic that does not inhibit CYP1A2. If it cannot be avoided, use a much lower tizanidine dose and monitor blood pressure and heart rate closely.
Questions à poser à votre pharmacien
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Autres interactions de Tizanidine
- Ciprofloxacin + Tizanidine Contre-indiquée
- Fluvoxamine + Tizanidine Contre-indiquée
- Pipemidic acid + Tizanidine Contre-indiquée
- Benzhydrocodone / acetaminophen + Tizanidine Majeure
- Brexanolone + Tizanidine Majeure
- Buprenorphine long-acting + Tizanidine Majeure
Autres interactions de Pefloxacin
- Clozapine + Pefloxacin Majeure
- Duloxetine + Pefloxacin Majeure
- Pefloxacin + Theophylline Majeure
- Asenapine + Pefloxacin Modérée
- Caffeine + Pefloxacin Modérée
- Cimetidine + Pefloxacin Modérée
Questions fréquentes
Can I take Pefloxacin with Tizanidine?
MediHelp rates the interaction as contraindicated. Pefloxacin and Tizanidine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Pefloxacin inhibits CYP1A2, the main enzyme clearing tizanidine, so tizanidine levels can rise markedly. This can cause severe hypotension, bradycardia and profound sedation, as seen with the related drug ciprofloxacin.
How serious is the interaction between Pefloxacin and Tizanidine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use an antibiotic that does not inhibit CYP1A2. If it cannot be avoided, use a much lower tizanidine dose and monitor blood pressure and heart rate closely.
What other medicines interact with Tizanidine?
MediHelp also lists interactions of Tizanidine with, for example, Ciprofloxacin, Fluvoxamine, Pipemidic acid. The full list is on the Tizanidine page.
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