Interactions médicamenteuses
Clozapine + Insulin degludec-liraglutide
Gravité: Majeure
Clozapine and Insulin degludec-liraglutide: major interaction.
Dernière mise à jour
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Résumé
Clozapine is strongly associated with weight gain, insulin resistance, hyperglycemia and sometimes diabetic ketoacidosis. This can substantially undermine glycemic control with insulin degludec-liraglutide.
Ce que signifie cette interaction, en termes simples
Clozapine and Insulin degludec-liraglutide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clozapine belongs to Central Nervous System; Insulin degludec-liraglutide belongs to Endocrine.
Pourquoi elle survient
Clozapine induces insulin resistance and may impair pancreatic insulin secretion and promote weight gain, opposing antidiabetic therapy.
Conduite à tenir
Monitor blood glucose frequently, particularly when clozapine is started or titrated, and increase antidiabetic therapy as needed. Reassess the regimen if hyperglycemia persists.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Insulin degludec-liraglutide
- Albiglutide + Insulin degludec-liraglutide Majeure
- Chlorpropamide + Insulin degludec-liraglutide Majeure
- Diazoxide + Insulin degludec-liraglutide Majeure
- Dulaglutide + Insulin degludec-liraglutide Majeure
- Ethanol + Insulin degludec-liraglutide Majeure
- Exenatide injectable + Insulin degludec-liraglutide Majeure
Autres interactions de Clozapine
- Clozapine + Deferiprone Contre-indiquée
- Clozapine + Irinotecan Contre-indiquée
- Clozapine + Pimozide Contre-indiquée
- Clozapine + Thioridazine Contre-indiquée
- Acalabrutinib + Clozapine Majeure
- Adagrasib + Clozapine Majeure
Questions fréquentes
Can I take Clozapine with Insulin degludec-liraglutide?
MediHelp rates the interaction as major. Clozapine and Insulin degludec-liraglutide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Clozapine is strongly associated with weight gain, insulin resistance, hyperglycemia and sometimes diabetic ketoacidosis. This can substantially undermine glycemic control with insulin degludec-liraglutide.
How serious is the interaction between Clozapine and Insulin degludec-liraglutide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose frequently, particularly when clozapine is started or titrated, and increase antidiabetic therapy as needed. Reassess the regimen if hyperglycemia persists.
What other medicines interact with Insulin degludec-liraglutide?
MediHelp also lists interactions of Insulin degludec-liraglutide with, for example, Albiglutide, Chlorpropamide, Diazoxide. The full list is on the Insulin degludec-liraglutide page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
