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Interactions médicamenteuses

Clozapine + Pefloxacin

Gravité: Majeure

Clozapine and Pefloxacin: major interaction.

Dernière mise à jour

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Résumé

Pefloxacin inhibits CYP1A2 and can raise clozapine concentrations, increasing the risk of sedation, hypotension, seizures, myocarditis and QT effects. Fluoroquinolones also have their own QT and seizure-lowering effects.

Ce que signifie cette interaction, en termes simples

Clozapine and Pefloxacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Clozapine belongs to Central Nervous System; Pefloxacin belongs to Anti Bacterial.

Niveau de preuve: Moderate

Pourquoi elle survient

Pefloxacin inhibits CYP1A2, decreasing clozapine clearance.

Conduite à tenir

Prefer an antibiotic that does not inhibit CYP1A2. If it must be used, reduce the clozapine dose and monitor clinical toxicity, clozapine levels and ECG.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Clozapine with Pefloxacin?

MediHelp rates the interaction as major. Clozapine and Pefloxacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pefloxacin inhibits CYP1A2 and can raise clozapine concentrations, increasing the risk of sedation, hypotension, seizures, myocarditis and QT effects. Fluoroquinolones also have their own QT and seizure-lowering effects.

How serious is the interaction between Clozapine and Pefloxacin?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an antibiotic that does not inhibit CYP1A2. If it must be used, reduce the clozapine dose and monitor clinical toxicity, clozapine levels and ECG.

What other medicines interact with Clozapine?

MediHelp also lists interactions of Clozapine with, for example, Deferiprone, Irinotecan, Pimozide. The full list is on the Clozapine page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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