Interactions médicamenteuses
Cimetidine + Pefloxacin
Gravité: Modérée
Cimetidine and Pefloxacin: moderate interaction.
Dernière mise à jour
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Résumé
Cimetidine has been reported to slow pefloxacin elimination, raising its levels and half-life. Increased fluoroquinolone adverse effects such as CNS effects are possible but this is rarely significant.
Ce que signifie cette interaction, en termes simples
Cimetidine and Pefloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cimetidine belongs to Gastrointestinal Tract; Pefloxacin belongs to Anti Bacterial.
Pourquoi elle survient
Cimetidine inhibits hepatic oxidative metabolism of pefloxacin, reducing its clearance.
Conduite à tenir
Monitor for CNS effects and tendon or gastrointestinal adverse effects, and consider lowering the pefloxacin dose in hepatic impairment or the elderly.
Questions à poser à votre pharmacien
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Autres interactions de Cimetidine
- Cimetidine + Dofetilide Contre-indiquée
- Cimetidine + Fezolinetant Contre-indiquée
- Alfentanil + Cimetidine Majeure
- Atazanavir + Cimetidine Majeure
- Carmustine + Cimetidine Majeure
- Cimetidine + Citalopram Majeure
Autres interactions de Pefloxacin
- Pefloxacin + Tizanidine Contre-indiquée
- Clozapine + Pefloxacin Majeure
- Duloxetine + Pefloxacin Majeure
- Pefloxacin + Theophylline Majeure
- Asenapine + Pefloxacin Modérée
- Caffeine + Pefloxacin Modérée
Questions fréquentes
Can I take Cimetidine with Pefloxacin?
MediHelp rates the interaction as moderate. Cimetidine and Pefloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cimetidine has been reported to slow pefloxacin elimination, raising its levels and half-life. Increased fluoroquinolone adverse effects such as CNS effects are possible but this is rarely significant.
How serious is the interaction between Cimetidine and Pefloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for CNS effects and tendon or gastrointestinal adverse effects, and consider lowering the pefloxacin dose in hepatic impairment or the elderly.
What other medicines interact with Cimetidine?
MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Fezolinetant, Alfentanil. The full list is on the Cimetidine page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
