Interactions médicamenteuses
Duloxetine + Pefloxacin
Gravité: Majeure
Duloxetine and Pefloxacin: major interaction.
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Résumé
Pefloxacin inhibits CYP1A2 and may raise duloxetine concentrations, increasing adverse effects such as nausea, dizziness, blood pressure rise and serotonergic toxicity. Strong CYP1A2 inhibitors such as fluoroquinolones like ciprofloxacin are labeled for avoidance with duloxetine.
Ce que signifie cette interaction, en termes simples
Duloxetine and Pefloxacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Duloxetine belongs to Central Nervous System; Pefloxacin belongs to Anti Bacterial.
Pourquoi elle survient
Inhibition of CYP1A2-mediated duloxetine metabolism by pefloxacin.
Conduite à tenir
Prefer an antibiotic that does not inhibit CYP1A2. If unavoidable, monitor for duloxetine adverse effects and consider dose reduction.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Duloxetine
- Duloxetine + Isocarboxazid Contre-indiquée
- Duloxetine + Linezolid Contre-indiquée
- Duloxetine + Methylene blue Contre-indiquée
- Duloxetine + Phenelzine Contre-indiquée
- Duloxetine + Procarbazine Contre-indiquée
- Duloxetine + Rasagiline Contre-indiquée
Autres interactions de Pefloxacin
- Pefloxacin + Tizanidine Contre-indiquée
- Clozapine + Pefloxacin Majeure
- Pefloxacin + Theophylline Majeure
- Asenapine + Pefloxacin Modérée
- Caffeine + Pefloxacin Modérée
- Cimetidine + Pefloxacin Modérée
Questions fréquentes
Can I take Duloxetine with Pefloxacin?
MediHelp rates the interaction as major. Duloxetine and Pefloxacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pefloxacin inhibits CYP1A2 and may raise duloxetine concentrations, increasing adverse effects such as nausea, dizziness, blood pressure rise and serotonergic toxicity. Strong CYP1A2 inhibitors such as fluoroquinolones like ciprofloxacin are labeled for avoidance with duloxetine.
How serious is the interaction between Duloxetine and Pefloxacin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an antibiotic that does not inhibit CYP1A2. If unavoidable, monitor for duloxetine adverse effects and consider dose reduction.
What other medicines interact with Duloxetine?
MediHelp also lists interactions of Duloxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Duloxetine page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
