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MediHelp Référence médicamenteuse

Interactions médicamenteuses

Cocaine + Desipramine

Gravité: Majeure

Cocaine and Desipramine: major interaction.

Dernière mise à jour Sources: US FDA label

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Résumé

Tricyclics block catecholamine reuptake, and cocaine does the same, so the sympathomimetic effects may be potentiated. With topical cocaine this is mainly relevant when large doses are absorbed, with risk of hypertension and arrhythmia.

Ce que signifie cette interaction, en termes simples

Cocaine and Desipramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Cocaine belongs to Central Nervous System; Desipramine belongs to Central Nervous System.

Niveau de preuve: Moderate

Pourquoi elle survient

Additive inhibition of norepinephrine reuptake, increasing adrenergic stimulation and arrhythmia risk.

Conduite à tenir

Avoid cocaine in patients taking desipramine, including topical anesthetic use, where an alternative anesthetic can be chosen. If unavoidable, use the minimum dose and monitor blood pressure and ECG.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Références

Questions fréquentes

Can I take Cocaine with Desipramine?

MediHelp rates the interaction as major. Cocaine and Desipramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tricyclics block catecholamine reuptake, and cocaine does the same, so the sympathomimetic effects may be potentiated. With topical cocaine this is mainly relevant when large doses are absorbed, with risk of hypertension and arrhythmia.

How serious is the interaction between Cocaine and Desipramine?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid cocaine in patients taking desipramine, including topical anesthetic use, where an alternative anesthetic can be chosen. If unavoidable, use the minimum dose and monitor blood pressure and ECG.

What other medicines interact with Desipramine?

MediHelp also lists interactions of Desipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Desipramine page.

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