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Interactions médicamenteuses

Cyclosporin + Daunorubicin

Gravité: Majeure

Cyclosporin and Daunorubicin: major interaction.

Dernière mise à jour

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Résumé

Cyclosporine can increase daunorubicin exposure and prolong its effects, increasing myelosuppression, mucositis and cardiotoxicity. It has been used deliberately to overcome drug resistance, which requires dose consideration.

Ce que signifie cette interaction, en termes simples

Cyclosporin and Daunorubicin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Cyclosporin belongs to Miscellaneous; Daunorubicin belongs to Oncology.

Niveau de preuve: Moderate

Pourquoi elle survient

Cyclosporine inhibits P-glycoprotein efflux, reducing daunorubicin clearance.

Conduite à tenir

Monitor blood counts and cardiac function closely and consider reducing the daunorubicin dose.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Cyclosporin with Daunorubicin?

MediHelp rates the interaction as major. Cyclosporin and Daunorubicin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cyclosporine can increase daunorubicin exposure and prolong its effects, increasing myelosuppression, mucositis and cardiotoxicity. It has been used deliberately to overcome drug resistance, which requires dose consideration.

How serious is the interaction between Cyclosporin and Daunorubicin?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and cardiac function closely and consider reducing the daunorubicin dose.

What other medicines interact with Cyclosporin?

MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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