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Interactions médicamenteuses

Dacomitinib + Pantoprazole

Gravité: Majeure

Dacomitinib and Pantoprazole: major interaction.

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Résumé

Proton pump inhibitors reduce dacomitinib exposure, which may lessen its antitumor efficacy. The effect stems from reduced absorption at higher gastric pH.

Ce que signifie cette interaction, en termes simples

Dacomitinib and Pantoprazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Dacomitinib belongs to Oncology; Pantoprazole belongs to Gastrointestinal Tract.

Niveau de preuve: Moderate

Pourquoi elle survient

Higher gastric pH from the proton pump inhibitor reduces dacomitinib solubility and absorption.

Conduite à tenir

Avoid pantoprazole; if acid suppression is needed, use a locally acting antacid or an H2 blocker with dacomitinib given at least 6 hours before or 10 hours after.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Dacomitinib with Pantoprazole?

MediHelp rates the interaction as major. Dacomitinib and Pantoprazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Proton pump inhibitors reduce dacomitinib exposure, which may lessen its antitumor efficacy. The effect stems from reduced absorption at higher gastric pH.

How serious is the interaction between Dacomitinib and Pantoprazole?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid pantoprazole; if acid suppression is needed, use a locally acting antacid or an H2 blocker with dacomitinib given at least 6 hours before or 10 hours after.

What other medicines interact with Pantoprazole?

MediHelp also lists interactions of Pantoprazole with, for example, Rilpivirine, Acalabrutinib, Atazanavir. The full list is on the Pantoprazole page.

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