Interactions médicamenteuses
Danazol + Flutamide
Gravité: Modérée
Danazol and Flutamide: moderate interaction.
Dernière mise à jour
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Résumé
Danazol is a CYP3A4 inhibitor and may increase flutamide exposure. In addition, danazol is an androgen and would oppose the intended antiandrogen effect of flutamide.
Ce que signifie cette interaction, en termes simples
Danazol and Flutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pourquoi elle survient
Danazol inhibits CYP3A4 and has pharmacodynamic androgenic activity opposing flutamide.
Conduite à tenir
Avoid the combination where possible because their effects are opposed. If used, monitor liver function tests.
Questions à poser à votre pharmacien
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Autres interactions de Flutamide
- Flutamide + Idelalisib Majeure
- Flutamide + Levoketoconazole Majeure
- Flutamide + Pexidartinib Majeure
- Flutamide + Pretomanid Majeure
- Flutamide + Valoctocogene roxaparvovec Majeure
- Apalutamide + Flutamide Modérée
Questions fréquentes
Can I take Danazol with Flutamide?
MediHelp rates the interaction as moderate. Danazol and Flutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danazol is a CYP3A4 inhibitor and may increase flutamide exposure. In addition, danazol is an androgen and would oppose the intended antiandrogen effect of flutamide.
How serious is the interaction between Danazol and Flutamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible because their effects are opposed. If used, monitor liver function tests.
What other medicines interact with Flutamide?
MediHelp also lists interactions of Flutamide with, for example, Idelalisib, Levoketoconazole, Pexidartinib. The full list is on the Flutamide page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
