Interactions médicamenteuses
Flutamide + Idelalisib
Gravité: Majeure
Flutamide and Idelalisib: major interaction.
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Résumé
Idelalisib is a strong CYP3A inhibitor and may raise flutamide exposure. Both drugs carry a risk of serious hepatotoxicity, so the combination may increase liver injury risk.
Ce que signifie cette interaction, en termes simples
Flutamide and Idelalisib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Flutamide belongs to Endocrine; Idelalisib belongs to Oncology.
Pourquoi elle survient
CYP3A4 inhibition by idelalisib reduces flutamide metabolism, compounded by additive hepatotoxicity.
Conduite à tenir
Avoid the combination where possible. If used, monitor liver enzymes frequently and stop either drug if significant elevation occurs.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Flutamide
- Flutamide + Levoketoconazole Majeure
- Flutamide + Pexidartinib Majeure
- Flutamide + Pretomanid Majeure
- Flutamide + Valoctocogene roxaparvovec Majeure
- Apalutamide + Flutamide Modérée
- Bupivacaine implant + Flutamide Modérée
Autres interactions de Idelalisib
- Alfuzosin + Idelalisib Contre-indiquée
- Cisapride + Idelalisib Contre-indiquée
- Dihydroergotamine + Idelalisib Contre-indiquée
- Dronedarone + Idelalisib Contre-indiquée
- Eletriptan + Idelalisib Contre-indiquée
- Eplerenone + Idelalisib Contre-indiquée
Questions fréquentes
Can I take Flutamide with Idelalisib?
MediHelp rates the interaction as major. Flutamide and Idelalisib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Idelalisib is a strong CYP3A inhibitor and may raise flutamide exposure. Both drugs carry a risk of serious hepatotoxicity, so the combination may increase liver injury risk.
How serious is the interaction between Flutamide and Idelalisib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If used, monitor liver enzymes frequently and stop either drug if significant elevation occurs.
What other medicines interact with Flutamide?
MediHelp also lists interactions of Flutamide with, for example, Levoketoconazole, Pexidartinib, Pretomanid. The full list is on the Flutamide page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
