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MediHelp Référence médicamenteuse

Interactions médicamenteuses

Flutamide + Levoketoconazole

Gravité: Majeure

Flutamide and Levoketoconazole: major interaction.

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Résumé

Levoketoconazole is a strong CYP3A4 inhibitor and may raise flutamide exposure. Both drugs carry a risk of hepatotoxicity, so combined use may increase the chance of liver injury.

Ce que signifie cette interaction, en termes simples

Flutamide and Levoketoconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Flutamide belongs to Endocrine; Levoketoconazole belongs to Endocrine.

Niveau de preuve: Low

Pourquoi elle survient

Levoketoconazole strongly inhibits CYP3A4, reducing flutamide metabolism, and both drugs are hepatotoxic.

Conduite à tenir

Avoid the combination if possible. If used, monitor liver function tests frequently and stop at signs of liver injury.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Flutamide with Levoketoconazole?

MediHelp rates the interaction as major. Flutamide and Levoketoconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Levoketoconazole is a strong CYP3A4 inhibitor and may raise flutamide exposure. Both drugs carry a risk of hepatotoxicity, so combined use may increase the chance of liver injury.

How serious is the interaction between Flutamide and Levoketoconazole?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible. If used, monitor liver function tests frequently and stop at signs of liver injury.

What other medicines interact with Flutamide?

MediHelp also lists interactions of Flutamide with, for example, Idelalisib, Pexidartinib, Pretomanid. The full list is on the Flutamide page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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