Interactions médicamenteuses
Flutamide + Pretomanid
Gravité: Majeure
Flutamide and Pretomanid: major interaction.
Dernière mise à jour
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Résumé
Pretomanid-containing regimens are associated with hepatotoxicity, and flutamide also carries a boxed warning for liver injury. Combined use may increase the chance of serious liver damage.
Ce que signifie cette interaction, en termes simples
Flutamide and Pretomanid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Flutamide belongs to Endocrine; Pretomanid belongs to Anti Bacterial.
Pourquoi elle survient
Additive hepatotoxicity.
Conduite à tenir
Avoid flutamide during pretomanid therapy and use another antiandrogen if needed. If unavoidable, monitor liver enzymes frequently.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Flutamide
- Flutamide + Idelalisib Majeure
- Flutamide + Levoketoconazole Majeure
- Flutamide + Pexidartinib Majeure
- Flutamide + Valoctocogene roxaparvovec Majeure
- Apalutamide + Flutamide Modérée
- Bupivacaine implant + Flutamide Modérée
Autres interactions de Pretomanid
- Amiodarone + Pretomanid Majeure
- Amobarbital + Pretomanid Majeure
- Amoxicillin-clavulanic acid + Pretomanid Majeure
- Apalutamide + Pretomanid Majeure
- Armodafinil + Pretomanid Majeure
- Azathioprine + Pretomanid Majeure
Questions fréquentes
Can I take Flutamide with Pretomanid?
MediHelp rates the interaction as major. Flutamide and Pretomanid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pretomanid-containing regimens are associated with hepatotoxicity, and flutamide also carries a boxed warning for liver injury. Combined use may increase the chance of serious liver damage.
How serious is the interaction between Flutamide and Pretomanid?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid flutamide during pretomanid therapy and use another antiandrogen if needed. If unavoidable, monitor liver enzymes frequently.
What other medicines interact with Flutamide?
MediHelp also lists interactions of Flutamide with, for example, Idelalisib, Levoketoconazole, Pexidartinib. The full list is on the Flutamide page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
