Interactions médicamenteuses
Flutamide + Pexidartinib
Gravité: Majeure
Flutamide and Pexidartinib: major interaction.
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Résumé
Both flutamide and pexidartinib can cause serious liver injury, and combined use may increase the risk of severe hepatotoxicity. Pexidartinib is restricted through a risk program because of cholestatic liver injury.
Ce que signifie cette interaction, en termes simples
Flutamide and Pexidartinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Flutamide belongs to Endocrine; Pexidartinib belongs to Oncology.
Pourquoi elle survient
Additive hepatotoxicity from two hepatotoxic drugs.
Conduite à tenir
Avoid combining them. If unavoidable, monitor liver tests closely and stop treatment at signs of liver injury.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Flutamide
- Flutamide + Idelalisib Majeure
- Flutamide + Levoketoconazole Majeure
- Flutamide + Pretomanid Majeure
- Flutamide + Valoctocogene roxaparvovec Majeure
- Apalutamide + Flutamide Modérée
- Bupivacaine implant + Flutamide Modérée
Autres interactions de Pexidartinib
- Allopurinol + Pexidartinib Majeure
- Amiodarone + Pexidartinib Majeure
- Amobarbital + Pexidartinib Majeure
- Amoxicillin-clavulanic acid + Pexidartinib Majeure
- Apalutamide + Pexidartinib Majeure
- Aprepitant + Pexidartinib Majeure
Questions fréquentes
Can I take Flutamide with Pexidartinib?
MediHelp rates the interaction as major. Flutamide and Pexidartinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both flutamide and pexidartinib can cause serious liver injury, and combined use may increase the risk of severe hepatotoxicity. Pexidartinib is restricted through a risk program because of cholestatic liver injury.
How serious is the interaction between Flutamide and Pexidartinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining them. If unavoidable, monitor liver tests closely and stop treatment at signs of liver injury.
What other medicines interact with Flutamide?
MediHelp also lists interactions of Flutamide with, for example, Idelalisib, Levoketoconazole, Pretomanid. The full list is on the Flutamide page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
