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Interactions médicamenteuses

Deutetrabenazine + Phenelzine

Gravité: Contre-indiquée

Deutetrabenazine and Phenelzine: contraindicated interaction.

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Résumé

Deutetrabenazine is contraindicated with MAO inhibitors per labeling. The combination may cause hypertensive reactions and unpredictable monoamine effects.

Ce que signifie cette interaction, en termes simples

Deutetrabenazine and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Deutetrabenazine belongs to Central Nervous System; Phenelzine belongs to Central Nervous System.

Niveau de preuve: Moderate

Pourquoi elle survient

VMAT2 inhibition alters monoamine storage while MAO inhibition prevents their breakdown, causing unpredictable monoamine and pressor effects.

Conduite à tenir

Avoid the combination and wait at least 14 days after stopping phenelzine before starting deutetrabenazine. Choose an alternative therapy if an MAOI is required.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Deutetrabenazine with Phenelzine?

MediHelp rates the interaction as contraindicated. Deutetrabenazine and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Deutetrabenazine is contraindicated with MAO inhibitors per labeling. The combination may cause hypertensive reactions and unpredictable monoamine effects.

How serious is the interaction between Deutetrabenazine and Phenelzine?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and wait at least 14 days after stopping phenelzine before starting deutetrabenazine. Choose an alternative therapy if an MAOI is required.

What other medicines interact with Phenelzine?

MediHelp also lists interactions of Phenelzine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Phenelzine page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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