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Interactions médicamenteuses

Deutetrabenazine + Safinamide

Gravité: Contre-indiquée

Deutetrabenazine and Safinamide: contraindicated interaction.

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Résumé

Deutetrabenazine is contraindicated with MAO inhibitors and within 14 days of stopping them. The combination may produce hypertension and excess sympathetic activity.

Ce que signifie cette interaction, en termes simples

Deutetrabenazine and Safinamide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Deutetrabenazine belongs to Central Nervous System; Safinamide belongs to Central Nervous System.

Niveau de preuve: Moderate

Pourquoi elle survient

Vesicular monoamine depletion by deutetrabenazine together with MAO inhibition causes unstable catecholamine effects.

Conduite à tenir

Do not combine and keep a 14-day interval after stopping the MAO inhibitor. Consider other therapy for the movement disorder.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Deutetrabenazine with Safinamide?

MediHelp rates the interaction as contraindicated. Deutetrabenazine and Safinamide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Deutetrabenazine is contraindicated with MAO inhibitors and within 14 days of stopping them. The combination may produce hypertension and excess sympathetic activity.

How serious is the interaction between Deutetrabenazine and Safinamide?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine and keep a 14-day interval after stopping the MAO inhibitor. Consider other therapy for the movement disorder.

What other medicines interact with Safinamide?

MediHelp also lists interactions of Safinamide with, for example, Amitriptyline, Amoxapine, Amphetamine polistirex. The full list is on the Safinamide page.

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