Référentiel des médicaments
Deutetrabenazine
Deutetrabenazine is a medicine in the class central nervous system. It is used for tardive dyskinesia.
- Classe médicamenteuse: Central Nervous System
- Indications: tardive dyskinesia
Dernière mise à jour Sources: US FDA label
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L'essentiel
- Classe médicamenteuse
- Central Nervous System
- Code ATC
- N07XX16
- Formes courantes
- comprimé
- Interactions connues
- 184 (Contre-indiquée: 8 · Majeure: 16 · Modérée: 147 · Mineure: 13)
- Noms commerciaux
- 3
- Pays et marchés
- 2
Indications
Mécanisme d'action
Precise mechanism unknown; believed related to reversible depletion of monoamines (dopamine, serotonin, norepinephrine, histamine) from nerve terminals. Metabolites alpha-HTBZ and beta-HTBZ reversibly inhibit VMAT2.
Posologie adulte habituelle (résumé de la notice)
Chorea in Huntington's disease or tardive dyskinesia, Austedo XR: start 12 mg once daily orally; increase weekly by 6 mg per day based on response and tolerability; maximum 48 mg per day
Grossesse et allaitement
- Grossesse
- Unknown No adequate human data. Deutetrabenazine had no clear effect on fetal development in rats, but the related tetrabenazine, given through pregnancy and lactation, increased stillbirths and offspring deaths. Use only if the benefit justifies the risk.
- Allaitement
- Unknown No data on milk levels or infant effects. US label: weigh breastfeeding against the mother's need. If used, watch the infant for drowsiness and poor feeding.
Effets indésirables signalés
- Somnolence
- Diarrhea
- Dry mouth
- Fatigue
- Nasopharyngitis
- Insomnia
Mises en garde encadrées
- Increases the risk of depression and suicidality in patients with Huntington's disease. Balance risks against the need to treat chorea; monitor for emergence or worsening of depression, suicidality or unusual behavior; inform patients, caregivers and families to report concerns promptly. Use caution with a history of depression or prior suicide attempts or ideation. Contraindicated in suicidal patients and in untreated or inadequately treated depression.
Contre-indications
- Huntington's disease patients who are suicidal or have untreated or inadequately treated depression
- Hepatic impairment
- Taking reserpine; wait at least 20 days after stopping reserpine
Précautions particulières
- Depression and suicidality in Huntington's disease; observe for new or worsening symptoms and consider discontinuing if they do not resolve
- QT prolongation: avoid in congenital long QT syndrome and history of cardiac arrhythmias
- Neuroleptic malignant syndrome: discontinue immediately if it occurs
Informez votre pharmacien ou votre médecin en cas de grossesse ou d'allaitement, de maladie rénale ou hépatique, d'allergies, ainsi que de tout autre médicament ou complément que vous prenez.
Principales interactions (184)
- Deutetrabenazine + Isocarboxazid Contraindicated
- Deutetrabenazine + Linezolid Contraindicated
- Deutetrabenazine + Phenelzine Contraindicated
- Deutetrabenazine + Rasagiline Contraindicated
- Deutetrabenazine + Safinamide Contraindicated
- Deutetrabenazine + Selegiline Contraindicated
- Deutetrabenazine + Tranylcypromine Contraindicated
- Deutetrabenazine + Valbenazine Contraindicated
- Abiraterone + Deutetrabenazine Major
- Bupropion + Deutetrabenazine Major
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Questions fréquentes
What is Deutetrabenazine used for?
Deutetrabenazine is a medicine in the class central nervous system. It is used for Tardive dyskinesia.
What side effects have been reported with Deutetrabenazine?
Somnolence, Diarrhea, Dry mouth, Fatigue, Nasopharyngitis, Insomnia. Serious warning: Increases the risk of depression and suicidality in patients with Huntington's disease.
Can Deutetrabenazine be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. No adequate human data. Deutetrabenazine had no clear effect on fetal development in rats, but the related tetrabenazine, given through pregnancy and lactation, increased stillbirths and offspring deaths. Use only if the benefit justifies the risk. Breastfeeding: Unknown. No data on milk levels or infant effects. US label: weigh breastfeeding against the mother's need. If used, watch the infant for drowsiness and poor feeding.
What does Deutetrabenazine interact with?
MediHelp lists 184 known interactions for Deutetrabenazine. Contraindicated: 8 · Major: 16 · Moderate: 147 · Minor: 13. The most serious include Isocarboxazid, Linezolid, Phenelzine.
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