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Interactions médicamenteuses

Deutetrabenazine + Tranylcypromine

Gravité: Contre-indiquée

Deutetrabenazine and Tranylcypromine: contraindicated interaction.

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Résumé

Deutetrabenazine depletes monoamines by inhibiting VMAT2, and combining it with an MAOI is contraindicated per labeling. The pairing may cause unpredictable blood pressure and heart rate changes and can destabilize mood or autonomic control.

Ce que signifie cette interaction, en termes simples

Deutetrabenazine and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Deutetrabenazine belongs to Central Nervous System; Tranylcypromine belongs to Central Nervous System.

Niveau de preuve: Moderate

Pourquoi elle survient

VMAT2 inhibition alters monoamine storage while MAO inhibition prevents breakdown, producing unpredictable adrenergic effects.

Conduite à tenir

Do not coadminister, and wait at least 14 days after stopping an MAOI before starting deutetrabenazine. Use another treatment for chorea or tardive dyskinesia if an MAOI is required.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Deutetrabenazine with Tranylcypromine?

MediHelp rates the interaction as contraindicated. Deutetrabenazine and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Deutetrabenazine depletes monoamines by inhibiting VMAT2, and combining it with an MAOI is contraindicated per labeling. The pairing may cause unpredictable blood pressure and heart rate changes and can destabilize mood or autonomic control.

How serious is the interaction between Deutetrabenazine and Tranylcypromine?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister, and wait at least 14 days after stopping an MAOI before starting deutetrabenazine. Use another treatment for chorea or tardive dyskinesia if an MAOI is required.

What other medicines interact with Tranylcypromine?

MediHelp also lists interactions of Tranylcypromine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Tranylcypromine page.

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