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Interactions médicamenteuses

Deutetrabenazine + Selegiline

Gravité: Contre-indiquée

Deutetrabenazine and Selegiline: contraindicated interaction.

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Résumé

Deutetrabenazine labeling prohibits use with MAO inhibitors and for 14 days after stopping one. Combining them may cause hypertension and other adrenergic effects.

Ce que signifie cette interaction, en termes simples

Deutetrabenazine and Selegiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Deutetrabenazine belongs to Central Nervous System; Selegiline belongs to Central Nervous System.

Niveau de preuve: Moderate

Pourquoi elle survient

Deutetrabenazine depletes and releases monoamines while MAO inhibition blocks their breakdown, so catecholamines can accumulate and cause a pressor response.

Conduite à tenir

Do not coadminister. Leave at least 14 days between stopping an MAOI and starting deutetrabenazine.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Deutetrabenazine with Selegiline?

MediHelp rates the interaction as contraindicated. Deutetrabenazine and Selegiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Deutetrabenazine labeling prohibits use with MAO inhibitors and for 14 days after stopping one. Combining them may cause hypertension and other adrenergic effects.

How serious is the interaction between Deutetrabenazine and Selegiline?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister. Leave at least 14 days between stopping an MAOI and starting deutetrabenazine.

What other medicines interact with Selegiline?

MediHelp also lists interactions of Selegiline with, for example, Amitriptyline, Amoxapine, Atomoxetine. The full list is on the Selegiline page.

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